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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 4
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Original Articles

PMA-SiO2–Mediated MCR in PEG-400: A Greener aza-Friedel–Crafts Reaction Leading to 3-Arylmethyl/Diarylmethyl Indoles

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Pages 513-523 | Received 24 Aug 2014, Published online: 31 Dec 2014
 

Abstract

A greener approach for the synthesis of 3-arylmethyl/diarylmethyl indoles has been achieved via a PMA-SiO2-mediated three-component reaction (the aza-Friedel–Crafts reaction) involving indoles, aldehydes, and N,N-disubstituted anilines in PEG-400. A variety of indole derivatives were prepared by using this operationally simple and straightforward methodology in acceptable yields.

GRAPHICAL ABSTRACT

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Corrigenda

ACKNOWLEDGMENTS

D. N. K. Reddy thanks A. Sanjay Reddy, Upadhya Thimanna, Vilas Dhanukar, and the management of CPS, DRL, Hyderabad, India, for support and encouragement.

SUPPORTING INFORMATION

Full experimental detail and spectral data for this article can be accessed on the publisher’s website.

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