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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 5
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Original Articles

Asymmetric Synthesis of Two Hydroxylated Pyrrolizidines From a C-Allyl Epoxypyrrolidine

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Pages 635-642 | Received 10 Sep 2014, Published online: 12 Jan 2015
 

Abstract

The efficient two-step preparation of a new pivotal C-allyl epoxypyrrolidine intermediate from an enantio-enriched epoxyaldehyde precursor is described. The synthetic potential of this building block is demonstrated with the first enantioselective synthesis of two hydroxylated pyrrolizidine relying on a regio- and stereocontrolled epoxide opening reaction.

GRAPHICAL ABSTRACT

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