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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 8
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Original Articles

Microwave Synthesis of 5-Substituted 1H-Tetrazoles Catalyzed by Bismuth Chloride in Water

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Pages 1023-1030 | Received 04 Sep 2014, Published online: 13 Feb 2015
 

Abstract

Bismuth chloride was used to catalyze the [2 + 3] cycloaddition between sodium azide with aryl nitriles, aliphatic nitriles, and vinyl nitriles. A number of 5-substituted 1H-tetrazoles were synthesized in water or isopropanol/water mixtures using microwave heating. Good yields were obtained for these reactions when heated for 1 h at 120–160 °C in a 3:1 isopropanol/water mixture. A few of the less reactive nitriles required longer reaction times for good yields.

GRAPHICAL ABSTRACT

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