One-Pot Green Synthesis of Novel Polysubstituted 1,2-Dihydronaphtho[2,1-b]furans

Abstract

A simple and highly efficient one-pot protocol for the synthesis of novel polysubstituted 1,2-dihydronaphtho[2,1-b] furans has been developed by three-component coupling reaction of 2-aminopyridines, naphthols, and glyoxal in the presence of guanidinium chloride as a polyfunctional organocatalyst under solvent-free conditions. The protocol avoids the use of expensive catalysts, toxic solvents, and chromatographic separation and provides a wide range of novel dihydronaphthofurans in good to excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• 1,2-Dihydronaphtho[2,1-b]furans
• 2-aminopyridines
• glyoxal
• naphthol

SUPPORTING INFORMATION

Full experimental detail, IR, CHN analysis, and ¹H and ¹³C NMR spectra for this article can be accessed on the publisher’s website.