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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 24
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Original Articles

Efficient Synthesis of Quinolines via a Knoevenagel/Staudinger/aza-Wittig Sequence

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Pages 2802-2809 | Received 24 Apr 2015, Published online: 14 Dec 2015
 

Abstract

A simple and efficient method for the construction of quinoline derivatives from 2-azidobenzaldehyde and various carbonyl compounds was developed. The process involves a Knoevenagel condensation of 2-azidobenzaldehyde with carbonyl compound and subsequently an intramolecular normal Staudinger/aza-Wittig reaction to form the quinolone ring in satisfactory yields.

GRAPHICAL ABSTRACT

SUPPLEMENTAL MATERIAL

Full experimental details, IR, CHN analysis, mass spectra, and 1H NMR and 13C NMR spectra for this article can be accessed on the publisher’s website.

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