ABSTRACT
A simple and efficient stereoselective total synthesis of sporiolide B and attempted synthesis of sporiolide A, from epichlorohydrin, using asymmetric synthetic approach is reported. The key reactions involved are Sharpless epoxidation, Jacobsen reaction, syn-allylation, Yamaguchi esterification, and Grubbs ring-closing metatheses reaction to result in the macrocyclic ring system.
GRAPHICAL ABSTRACT
![](/cms/asset/54bd11e7-e19c-49e7-be22-d87d716a0234/lsyc_a_1135958_uf0001_b.png)