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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 7
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Original Articles

Silica sulfuric acid as a highly efficient catalyst for the synthesis of diarylacetic acids

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Pages 604-612 | Received 10 Feb 2016, Published online: 13 Apr 2016
 

ABSTRACT

An efficient heterogeneous method for the synthesis of diarylacetic acids was developed utilizing silica sulfuric acid as a catalyst. The reaction is highly efficient with a small amount of catalyst for the combination of a variety of electron-neutral to electron-rich arenes with glyoxylic acid. The reaction can also be utilized to synthesize unsymmetric derivatives from activated mandelic acids in good to excellent yields.

GRAPHICAL ABSTRACT

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