Synthesis of C3-dihydrofuran substituted coumarins via multicomponent approach

ABSTRACT

An efficient method was developed for the synthesis of dihydrofuran substituted coumarin from a one-pot, four-component reaction of 2-hydroxy aromatic aldehydes, 6-methyl, 4-hydroxy pyranone, aromatic aldehyde, and pyridinium ylide in the presence of tri-ethylamine under microwave irradiation. The reaction proceeds under solvent-free conditions to afford C3-dihydrofuran substituted coumarin in a diastereoselective manner in good yields (71–89%).

GRAPHICAL ABSTRACT

KEYWORDS:

• C3-dihydrofuran substituted coumarin
• microwave-assisted synthesis
• multicomponent
• pyridinium ylide

Acknowledgment

We thank Sri Venkateswara University for recording NMR and MS spectra.