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ABSTRACT
An efficient and greener protocol for easy access to 3-susbstituted-3-hydroxy-2-oxindoles by the reaction with various substituted isatins and acetophenones is described. This protocol is widely applicable for a variety of isatins and acetophenones using water as a reaction media and 1,4-diazabicyclo[2.2.2]octane (DABCO) as catalyst with shorter reaction time and good to excellent yield of products.
GRAPHICAL ABSTRACT
Acknowledgments
K. N. T. thanks the Director, CSIR-CDRI, Lucknow (mentor institute of NIPER, Raebareli), and P. K. Shukla, Project Director, NIPER, Raebareli for their support and encouragement in carrying out this research work. SAIF-CSIR-CDRI, Lucknow, is greatly acknowledged for providing spectral data. This is NIPER-RBL Communication No. 02. The authors declare no conflict of interest.