Efficient ecofriendly synthesis of pyrazole acryloyl analogs by amino acid catalysis

Faryal ChaudhryInstitute of Chemistry, University of the Punjab, Lahore, Pakistan;Department of Chemistry, Kinnaird College for Women, Lahore, Pakistan

Nadia AsifInstitute of Chemistry, University of the Punjab, Lahore, Pakistan

Syed Salman ShafqatDepartment of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak, Sarawak, Malaysia

Amir Azam KhanDepartment of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Malaysia Sarawak, Sarawak, Malaysia

Munawar Ali MunawarInstitute of Chemistry, University of the Punjab, Lahore, PakistanCorrespondence[email protected]

Misbahul Ain KhanInstitute of Chemistry, University of the Punjab, Lahore, Pakistan;Department of Chemistry, Islamia University of Bahawalpur, Bahawalpur, Pakistan

ABSTRACT

An easy and effective green approach of Knoevenagel condensation and arylidene formation with the substrates involves pyrazole-3-carbaldehydes and active methylenes under catalytic action of glycine (the simplest amino acid) in dimethylsulfoxide. These reactions were successfully carried out at room temperature.

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Efficient ecofriendly synthesis of pyrazole acryloyl analogs by amino acid catalysis

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Efficient ecofriendly synthesis of pyrazole acryloyl analogs by amino acid catalysis

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