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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 8
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SYNTHETIC COMMUNICATIONS REVIEWS

Synthetic chemistry of pyrimidines and fused pyrimidines: A review

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Pages 645-672 | Received 31 Jan 2016, Published online: 05 May 2016
 

ABSTRACT

This review is an attempt to compile the literature of various synthetic procedures of pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of heterocyclic scaffolds that demonstrates a broad range of biological and pharmacological activities such as anticancer, anxiolytic, antioxidant, antiviral, antifungal, anticonvulsant, antidepressant, and antibacterial activities. According to World Health Organization reports, cancer remains a major cause of death in worldwide and there is a need to develop an effective drug against cancer. The literature indicated that pyrimidine motifs acts as anticancer agents, which motivates the researchers to design a series of pyrimidine heterocycles.

GRAPHICAL ABSTRACT

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