Review of synthesis and various biological activities of spiro heterocyclic compounds comprising oxindole and pyrrolidine moities

ABSTRACT

Spirocyclic compounds isolated from plant and animal origins have important applications in medicinal chemistry. Spiro compounds having cyclic structures fused at a central carbon are of recent interest because of their interesting conformational features and their structural implications for biological systems. Spiro heterocycles like spiropyrrolidines and oxindole moieties have been found to play fundamental roles in biological processes and have exhibited diversified biological activity and pharmacological and therapeutical properties. In view of these facts we decided to present a representative synthetic scheme and various biological activities of the heterocycles like spiropyrrolidines and oxindole moieties derivatives, especially in relation to microbial infections like cancer and tubercular, viral, HIV, bacterial, and fungal infections.

GRAPHICAL ABSTRACT

KEYWORDS:

• Azomethine ylide
• 1,3-dipolar cycloaddition
• oxindole
• spirocyclic
• spiropyrrolidines