Efficient synthesis of xanthenedione derivatives using cesium salt of phosphotungstic acid as a heterogeneous and reusable catalyst in water

ABSTRACT

Cs_2.5H_0.5PW₁₂O₄₀ has been reported to be an efficient catalyst for the synthesis of 1,8-dioxo-octahydroxanthene from aldehydes and 1,3-cyclohexanedione/dimedone in water. This approach is environmentally benign with clean synthetic procedure, short reaction time, easy workup procedure, excellent yield, and regeneration of catalyst, which made this protocol efficient and safe.

GRAPHICAL ABSTRACT

KEYWORDS:

• Aldehydes
• Cs_2.5H_0.5PW₁₂O₄₀
• dimedone
• 1,8-dioxo-octahydroxanthene

Acknowledgments

We are grateful to Dr. P. K. Shukla, project director of NIPER-Raebareli, for support and motivation. SAIF-CSIR-CDRI, Lucknow is greatly acknowledged for providing spectral data.