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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 23
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Original Articles

Efficient catalyst-free synthesis of diversified bis (spirooxindoles) via one-pot, three-component reaction

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Pages 1880-1886 | Received 10 Jul 2016, Published online: 16 Sep 2016
 

ABSTRACT

A catalyst-free, one-pot synthesis of bis-spirooxindoles has been carried out by a three-component reaction of bis-isatins, malononitrile, and various cyclic enolizable carbonyl compounds in ethylene glycol at 100 °C. The protocol provides an easy and simple route for the synthesis of such complex compounds, in short reaction times and high yields. No chromatographic techniques have been employed for the purification of the compounds.

GRAPHICAL ABSTRACT

Acknowledgment

The authors acknowledge DU-DST for providing HRMS-LC analysis.

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