ABSTRACT
A facile and practical approach to the synthesis of a wide range of functionalized quinolines was developed via a tandem heteroannulation reaction of o-aminoarylketones with diverse α-methylene ketones in high yields by using tetrabutylammonium peroxydisulfate as a versatile reagent (25 mol%) at ambient temperature under solvent-free conditions. This protocol was applied to the synthesis of drug-like molecules, which are key intermediates of alkaloid camptothecin.
GRAPHICAL ABSTRACT
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Acknowledgments
One of the authors (G. V.) thanks the commissioner, Collegiate Education, government of Telangana for support and encouragement. We are also indebted to Prof. D. Ashok for valuable suggestions.