Synthetic strategies toward the synthesis of enoxacin-, levofloxacin-, and gatifloxacin-based compounds: A review

ABSTRACT

Enoxacin, levofloxacin, and gatifloxacin represent one of the most important prerogative scaffolds in drug development. They possess broad spectrum antimicrobial and anti-inflammatory activities. They inhibit bacterial growth by blocking their topoisomerase enzyme which is necessary for the proper functioning of bacterial DNA. In this article, we have reviewed the synthetic approaches involved in the synthesis of derivatives of enoxacin, levofloxacin, and gatifloxacin.

GRAPHICAL ABSTRACT

KEYWORDS:

• Antibacterial activity
• enoxacin
• fluoroquinolones
• gatifloxacin
• levofloxacin

Acknowledgment

The support from Government College University, Faisalabad and Higher Education Commission, Pakistan is gratefully acknowledged.