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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 47, 2017 - Issue 12
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Original Articles

Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

Imène SehoutLaboratoire de synthèse de molécules d’intérêts biologiques, Faculté des Sciences Exactes, Université Frères Mentouri Constantine 1, Constantine, Algeria
,
Raouf BoulcinaLaboratoire de synthèse de molécules d’intérêts biologiques, Faculté des Sciences Exactes, Université Frères Mentouri Constantine 1, Constantine, Algeria
,
Boudjemaa BoumoudLaboratoire de synthèse de molécules d’intérêts biologiques, Faculté des Sciences Exactes, Université Frères Mentouri Constantine 1, Constantine, Algeria
,
Taous BoumoudLaboratoire de synthèse de molécules d’intérêts biologiques, Faculté des Sciences Exactes, Université Frères Mentouri Constantine 1, Constantine, Algeria
&
Abdelmadjid DebacheLaboratoire de synthèse de molécules d’intérêts biologiques, Faculté des Sciences Exactes, Université Frères Mentouri Constantine 1, Constantine, AlgeriaCorrespondence[email protected]
Pages 1185-1191 | Received 04 Feb 2017, Published online: 23 May 2017
 
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ABSTRACT

Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst.

GRAPHICAL ABSTRACT

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