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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 47, 2017 - Issue 12
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Original Articles

Synthesis and antimicrobial evaluation of novel 3-(arylideneamino)-3a,8a-dihydroxy-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazole-2,8-diones and their 2-thioxo analogues

Yeshwinder SainiDepartment of Chemistry, University of Jammu, Jammu, India
,
Rajni KhajuriaDepartment of Chemistry, University of Jammu, Jammu, India
,
Ramneet KaurDepartment of Chemistry, University of Jammu, Jammu, India
,
Sanjana KaulSchool of Biotechnology, University of Jammu, Jammu, IndiaCorrespondence[email protected]
,
Tanwi SharmaSchool of Biotechnology, University of Jammu, Jammu, India
,
Suruchi GuptaSchool of Biotechnology, University of Jammu, Jammu, India
,
Vivek K. GuptaX-ray Crystallography Laboratory, Department of Physics and Electronics, University of Jammu, Jammu, India
,
Rajni KantX-ray Crystallography Laboratory, Department of Physics and Electronics, University of Jammu, Jammu, India
&
Kamal K. KapoorDepartment of Chemistry, University of Jammu, Jammu, IndiaCorrespondence[email protected]
 show all
Pages 1159-1168 | Received 13 Feb 2017, Published online: 10 May 2017
 
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ABSTRACT

The preparation of some novel 3-(arylideneamino)-3a,8a-dihydroxy-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazole-2,8-diones 8(i–xiv) and 3-(arylideneamino)-3a,8a-dihydroxy-2-thioxo-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazol-8(2H)-ones 9(i–xiv) have been reported through one-pot catalyst-free reaction of aldehydes, semicarbazide hydrochloride/thiosemicarbazide with ninhydrin. All the synthesized compounds have been screened for antimicrobial activity and some of them were observed to possess broad spectrum antibacterial potential as well as significant antagonistic potential against fungal pathogens.

GRAPHICAL ABSTRACT

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