Efficient PEG-mediated green synthesis of isoaurones: First synthesis of 4′,6-dihydroxy-4-methoxyisoaurone isolated from Trichosanthes kirilowii

ABSTRACT

An efficient and green protocol for the synthesis of isoaurones by condensation of benzofuranone with benzaldehydes using polyethylene glycol (PEG) is demonstrated. Excellent yields, no reagents/additional catalysts, E-selectivity, short reaction times, and no work-up/extraction makes an attractive benign procedure. Additionally, 4′,6-dihydroxy-4-methoxyisoaurone isolated from Trichosanthes kirilowii has been synthesized for the first time and confirmed its geometry as E.

GRAPHICAL ABSTRACT

KEYWORDS:

• 4′,6-Dihydroxy-4-methoxyisoaurone
• green chemistry
• isoaurone
• polyethylene glycol
• Trichosanthes kirilowii

Acknowledgments

We sincerely thank Sri Gokaraju Ganga Raju, Chairman, and Mr. Gokaraju Rama Raju, Director, Laila Research Centre, for support and encouragement.