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ABSTRACT
A facile and efficient method for the regioselective acetoxylation of 1-benzyl 1,2,3-triazoles through C–H bond activation was developed. Cu(OAc)2 and 1,2,3-triazole were applied as catalyst and elegant directing group, respectively, to convert aromatic C–H bonds directly into highly regioselective C–O bonds. The conversion can result in the synthesis of 1,2,3-triazoles bearing acetoxyl groups.
GRAPHICAL ABSTRACT
Additional information
Funding
We are grateful for the financial support provided by the National Natural Science Foundation of China (Grant Nos. 21262020 and 21662020).
