Cu(II)-β-cyclodextrin-catalyzed synthesis of spiro[indoline-3,4′-pyrano[3,2-c]chromene]-3′-carbonitrile derivatives

ABSTRACT

Cu(II)-β-cyclodextrin-catalyzed synthesis of spiro[indoline-3,4′-pyrano[3,2-c]chromene]-3′-carbonitriles through the reaction of isatin derivatives, 4-hydroxycoumarin, and malononitrile in ethanol at room temperature.

GRAPHICAL ABSTRACT

KEYWORDS:

• Cu(II)-β-cyclodextrin
• isatin
• spiro
• synthesis

Acknowledgment

This paper is dedicated to the memory of our wonderful teacher in Chemistry and Medicinal Chemistry, Professor Abbas Shafiee.

Additional information

Funding

The authors acknowledge the partial financial support from Tehran University of Medical Sciences Research Council and International Campus (TUMS-IC).