Design and applications of new phosphine-free tetradentate Pd-catalyst: Regioselective C–H activation on 1-substituted 1,2,3-triazoles and indoles(NH-Free)

ABSTRACT

This article describes the synthesis of a new phosphine free tetradentate Pd catalyst using dl-2,3-diaminopropionic acid. The complex was characterized by Mass, IR, and ¹H NMR. The catalyst is air stable at room temperature and non-hygroscopic. Application of this new catalyst to regioselective C–H activation on 1-substituted 1,2,3-triazole and indoles with aryl iodides to get corresponding C-5 and C-2 arylated products with satisfactory yields. All the products were characterized by spectroscopic studies.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1,2,3-Triazoles
• aryl iodides
• C-H bond activation
• palladium acetate
• tetradentate ligand

Acknowledgments

The authors thanks to GVKBIO, Hyderabad, for providing the facilities to do research. Also thank full to GBR and YSN for continuous support.