ABSTRACT
One-pot synthesis of α-aminophosphonates directly from aryl nitro compounds, aldehydes/ketones, and diethyl phosphite using sodium dithionite through reduction and followed by Kabachnik–Fields reaction under metal-free conditions is reported. The major advantages are excellent yield, high chemoselectivity, neutral reaction medium, and simple experimental procedure. This methodology consists of the following steps: 1) amine formation from nitro compound, 2) imine formation from amine and aldehyde/ketone, 3) phosphate addition to imine.
GRAPHICAL ABSTRACT
Acknowledgments
One of the author (Murali Krishna Kolli) gratefully acknowledged to Dr. Shambabu Joseph Maddirala and GVK Biosciences Pvt Ltd, Hyderabad for their continues support and motivation.