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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 2
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Original Articles

Catalyst-free synthesis of novel 4H-indeno[1,2-b]furan-4-ones and furo[2,3-d]pyrimidines in water

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Pages 155-160 | Received 04 Aug 2017, Published online: 14 Dec 2017
 

ABSTRACT

An operationally simple, catalyst-free, and efficient protocol for the synthesis of novel 4H-indeno[1,2-b]furan-4-one and furo[2,3-d]pyrimidine derivatives by a one-pot reaction of 2-aminopyridines, 1,3-indandione, or barbituric acid and phenylglyoxal monohydrate in water at reflux, involving domino aldol condensation, Michael addition, and ring-closing reactions is described. This transformation has several advantages, including high yield, short reaction duration, simple workup, and simple purification.

GRAPHICAL ABSTRACT

Acknowledgments

The authors thank the Research Council of Payame Noor University for financial support.

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