Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 2
342
Views
18
CrossRef citations to date
0
Altmetric
Original Articles

Organocatalytic mediated green approach: A versatile new L-valine promoted synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans

, , , , , , & show all
Pages 188-196 | Received 10 Aug 2017, Published online: 26 Dec 2017
 

ABSTRACT

The discovery of a new L-valine promoted facile and versatile green synthesis of diversified 2-amino-3-cyano-4H-pyrans using a one pot multicomponent-tandem reaction of aromatic aldehydes, malononitrile, and diverse electron-rich enolizable carbonyl compounds is described. To the best of our knowledge this is the first report on the use of native L-valine as a catalyst in organic synthesis. Environmental friendly, mild reaction conditions, use of easily available inexpensive starting materials, short reaction time, excellent yields, high atom economy, and recyclability of organocatalyst are the major advantages of the disclosed protocol.

GRAPHICAL ABSTRACT

Additional information

Funding

The authors are thankful to SAIF, PU, Chandigarh for spectral data. The authors also acknowledge the financial support from UGC, New Delhi in form of fellowships for Fatima Tufail and Amit Kumar Sharma. Jyoti Tiwari and Shailesh Singh thank CSIR, New Delhi for SRF and JRF, respectively.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.