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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 3
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Original Articles

Spirooxindole-fused pyrazolo pyridine derivatives: NiO–SiO2 catalyzed one-pot synthesis and antimicrobial activities

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Pages 255-266 | Received 21 Jul 2017, Accepted 05 Oct 2017, Published online: 08 Jan 2018
 

ABSTRACT

We describe here a one-pot synthesis of 13 spirooxindole-fused pyrazolo pyridine derivatives using NiO–SiO2 catalyst via three-component reaction of isatin, 5-amino-3-methylpyrazole, and malononitrile. This multicomponent one-pot protocol also features shorter reaction time, good yield, and simple work-up using a recoverable and reusable solid acid heterogeneous catalyst. The NiO–SiO2 catalyst was characterized using different instrumental techniques such as X-ray diffraction study, surface area analysis, transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, UV-DRS (diffuse reflectance spectroscopy), and energy dispersive X-ray analysis (EDX). The new compounds were tested for in-vitro anti-microbial activity.

GRAPHICAL ABSTRACT

Additional information

Funding

R. Trivedi acknowledges the 12th 5 years plan project Indus Magic, CSC-0123 of CSIR-IICT for financial support. S. Yagnam thanks the UGC and A. M. Akondi thanks the CSIR, India for the award of Research Fellowship.

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