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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 3
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Original Articles

Efficient synthesis of tertiary amine by direct N-alkylation of secondary amine with carboxylic acid using Ni (0) encat catalyst

, , &
Pages 267-277 | Received 06 Aug 2017, Published online: 02 Jan 2018
 

ABSTRACT

In this article, direct N-alkylation of secondary amines with carboxylic acid is described. Readily available diversified carboxylic acid has been explored on variant secondary amines using encapsulated Nickel as catalyst and inexpensive sodium borohydride as the hydride source. High yields, mild reaction conditions, tolerance to sensitive functional group and facile operational procedure are the significance of the present methodology.

GRAPHICAL ABSTRACT

Acknowledgment

We acknowledge the management of Dr. Rafiq Zakaria College for women Aurangabad.

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