Heteropoly acid supported on activated natural clay-catalyzed synthesis of 3,4-dihydropyrimidinones/thiones through Biginelli reaction under solvent-free conditions

ABSTRACT

Dihydropyrimidinones/thiones (DHPM’s) have been prepared by one-pot condensation of methyl acetoacetate, aldehydes, urea/thiourea in the presence of heteropoly-11-tungsto-1-vanadophosphoric acid, H₄[PVW₁₁O₄₀] · 32H₂O, (HPV) supported on activated natural clay (HPVAC) under solvent-free reaction condition have been proposed. The DHPM derivatives were identified through elemental analysis and melting point measurements and characterized by FT-IR, ¹H-NMR, ¹³C-NMR spectroscopic methods.

GRAPHICAL ABSTRACT

KEYWORDS:

• 3,4-Dihydropyrimidinones/thiones
• heteropoly acid
• multi-component synthesis
• natural clay

Additional information

Funding

The authors Ponnusamy Sami and Karuppaiah Selvakumar thank University Grants Commission, New Delhi, India, for the award of major research project (F. No. 42-349/2013(SR)) and financial assistance. We also thank Managing Board, VHNSN College, Virudhunagar for infrastructural facilities.