Metal-free synthesis of 2-aminothiadiazoles via TBHP-Mediated oxidative C-S bond formation

ABSTRACT

An efficient one-pot synthesis of 2-amino-1,3,4-thiadiazoles from easily available aldehydes and thiosemicarbazide using TBHP as an oxidant has been described. Notably, these reactions were carried out at room temperature using ethanol as solvent. This is the first example for one-pot synthesis of 2-amino-1,3,4-thiadiazole derivatives from aldehydes. This new synthetic methodology provides a simple procedure utilizing a safer oxidizing system that affords the target products in mild reaction condition with satisfactory yields and wide substrate scope.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1,3,4-Thiadiazole
• aldehydes
• c-s bond formation
• metal free
• TBHP

Acknowledgments

VNT thanks to University Grant Commission, New Delhi, India for providing financial support under UGC-Major research scheme. NTH and SMG thank to University Grant Commission, New Delhi, India for providing fellowship under basic science research (UGC-BSR).