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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 3
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Original Articles

Novel one-pot expeditious synthesis of 2,4-disubstituted thiazoles through a three-component reaction under solvent free conditions

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Pages 302-308 | Received 06 Sep 2017, Published online: 08 Jan 2018
 

ABSTRACT

An expeditious one pot method has been developed for the synthesis of 2,4-disubstituted thiazoles under solvent free conditions via a multicomponent approach. Substituted thiazoles were synthesized with high yields by the reaction of cyclic ketones, thiosemicarbazide, and phenacyl bromides or 3-(2-bromoacetyl)-2H-chromen-2-ones in a shorter reaction time with high purity via simple purification technique.

GRAPHICAL ABSTRACT

Acknowledgments

The authors are thankful to the Director, National Institute of Technology, Warangal, Telangana, India for providing the facilities. K. S. thanks to the MHRD, India for fellowship.

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