ABSTRACT
Triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine which can serve as key precursor for many monodentate and multidentate imaging agents for Aβ plaques in human brain has been readily synthesized with cost-effective starting materials. The important non-radioactive monodentate positron emission tomography agent [F]florbetapir ([F]AV-45) has also been prepared by our new method.
GRAPHICAL ABSTRACT
![](/cms/asset/7bae57e9-1373-4cef-8379-d12b115d9443/lsyc_a_1404107_uf0001_b.png)