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ABSTRACT
The iridium-catalyzed asymmetric hydrogenation of β-keto esters with chiral tridentate P,N,N-ligands (f-amphox) has been developed. Under the optimized conditions, a wide range of β-keto esters can be hydrogenated smoothly, affording the corresponding β-hydroxy esters in good to excellent enantioselectivities (up to 95% ee).
GRAPHICAL ABSTRACT
Additional information
Funding
The authors are grateful for the financial support from the National Natural Science Foundation of China (Nos. 21403022, 21572226, and 21772196), Natural Science Foundation of Liaoning Province of China (No. 2015020194), and program of Star of Dalian Youth Science and Technology (No. 2016RQ062).