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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 5
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Original Articles

An expedient synthesis of spirooxindoles incorporating 2-amino pyran-3-carbonitrile unit employing dialkyl acetone-1,3-dicarboxylates

, , &
Pages 582-587 | Received 05 Oct 2017, Published online: 09 Feb 2018
 

ABSTRACT

Spirooxindoles are a class of molecules possessing significant biological effects such as antiviral, antifungal, antibacterial and anticancer properties. Herein we report a series of spirooxindole molecules having 2-amino pyran-3-carbonitrile and with two ester groups. These molecules were prepared by the reaction of dialkyl acetone-1,3-dicarboxylate and isatilidenes in the presence of triethyl amine.

GRAPHICAL ABSTRACT

Acknowledgments

The authors acknowledge SICC, University of Kerala for spectral and elemental analysis. A. L. B. thank the UGC for Junior Research fellowship.

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