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ABSTRACT
A simple and efficient approach for the construction of spirooxindole-pyrrolizidines and dispirooxindole-piperazines by cycloaddition reaction of azomethine ylide generated by isatin and proline has been demonstrated successfully. The formation of two different types of frameworks by two different modes of cycloaddition is explored. The developed protocol highlights simple reaction conditions, easy workup processes, and very good yields of products.
GRAPHICAL ABSTRACT
Acknowledgments
We are thankful to Dr. SJS Flora, Director, NIPER, Raebareli for his support and encouragement in carrying out this research work. TPP, SP, and PS are thankful to the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India for providing fellowship. SAIF-CSIR-CDRI, Lucknow is greatly acknowledged for providing spectral data. Communication no. NIPER-R/Communication/034.