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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 7
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Original Articles

Lewis acid catalyzed Povarov reaction of pentafulvenes and spiro[2,4]-hepta-[4,6]-diene: An efficient access to cyclopentene fused quinolines

, , &
Pages 816-829 | Received 20 Dec 2017, Published online: 06 Mar 2018
 

ABSTRACT

An efficient protocol for the Lewis acid catalyzed three-component aza-Diels-Alder reaction of pentafulvenes as dienophile has been developed. Cyclopentene fused tetrahydroquinolines were formed in good yields with excellent diastereoselectivities. The method was extended to spiro[2,4]hepta-4,6-diene, by which 3,4-dihydroquinoline derivatives were obtained. The aromatization of cycloadducts furnished corresponding quinoline derivatives.

GRAPHICAL ABSTRACT

Acknowledgments

BTV and GG thank CSIR for research fellowship. Dr. Sunil Varughese is greatly acknowledged for single X-ray crystal analyses. The authors also thank Mrs. Saumini Mathew, Mr. Saran P.Raveendran, Mrs. S. Viji and Ms. S. Aathira of CSIR-NIIST for recording NMR and Mass spectra.

Additional information

Funding

Financial assistance from the Science and Engineering Research Board (SERB) New Delhi (SB/S1/OC-24/2014) and the Council of Scientific and Industrial Research, New Delhi (12th FYP project, ORIGIN-CSC-0108) are greatly acknowledged.

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