ABSTRACT
An efficient protocol for the Lewis acid catalyzed three-component aza-Diels-Alder reaction of pentafulvenes as dienophile has been developed. Cyclopentene fused tetrahydroquinolines were formed in good yields with excellent diastereoselectivities. The method was extended to spiro[2,4]hepta-4,6-diene, by which 3,4-dihydroquinoline derivatives were obtained. The aromatization of cycloadducts furnished corresponding quinoline derivatives.
GRAPHICAL ABSTRACT
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Acknowledgments
BTV and GG thank CSIR for research fellowship. Dr. Sunil Varughese is greatly acknowledged for single X-ray crystal analyses. The authors also thank Mrs. Saumini Mathew, Mr. Saran P.Raveendran, Mrs. S. Viji and Ms. S. Aathira of CSIR-NIIST for recording NMR and Mass spectra.