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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 7
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Original Articles

Highly efficient Brønsted acid and Lewis acid catalysis systems for the Friedländer Quinoline synthesis

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Pages 830-837 | Received 06 Dec 2017, Published online: 06 Mar 2018
 

ABSTRACT

The efficient and green Brønsted acid or Lewis acid catalysis systems for the Friedländer synthesis of 2,3,4-trisubstituted quinolines from the condensation of 2-aminoarylketones and β-ketoesters/ketones had been developed. The results confirmed that 4-toluenesulfonic acid, magnesium chloride, and cupric nitrate were the desired catalyst independently. This protocol had the advantages of mild conditions, operational simplicity, and excellent yields.

GRAPHICAL ABSTRACT

Additional information

Funding

The work was supported by the Youth Science and Technology Talent Development Project in Education Department of Guizhou Province (Grant No.qianjiaohe KY zi [2017] number 261), the Union Foundation of Science and Technology Department of Guizhou Province (Grant No. qiankehe LH zi [2015] number 7614) and Innovation Team of Liupanshui Normal University (Grant No. LPSSYKJTD201601).

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