Green procedure for highly efficient, rapid synthesis of imidazo[1,2-a]pyridine and its late stage functionalization

ABSTRACT

We unfold a rapid synthetic protocol for the preparation of imidazo[1,2-a]pyridine in cyclohexane. This methodology includes several advantages like shorter reaction time, catalyst free, broader substrate scope, and good yields of the desired products. Late stage functionalization of imidazo[1,2-a]pyridine has also been performed through C–H bond activation and C–C cross-coupling reactions.

GRAPHICAL ABSTRACT

KEYWORDS:

• C–H bond activation
• green synthesis
• imidazo[1,2-a]pyridine
• iodine catalyzed

Acknowledgment

PG is thankful to UGC for his fellowship.

Additional information

Funding

We thank the SERB, New Delhi for financial support (EMR/2016/001250).