Rapid synthesis of new 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazole as potential antibacterial drugs through one-pot cyclization and Suzuki–Miyaura coupling

ABSTRACT

Original 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazoles were prepared by reacting 1-(2,5-dibromo-4-nitro-1H-imidazol-1-yl)propan-2-ol and various arylboronic acids through “one-pot” cyclization and Suzuki–Miyaura reactions under microwave irradiation.

GRAPHICAL ABSTRACT

KEYWORDS:

• 4-Nitroimidazole
• boronic acids
• imidazo[5,1-b]oxazole
• microwave
• Suzuki–Miyaura

Acknowledgment

The authors thank V. Remusat for NMR spectra recording and the Spectropole team for various analytical measurements.

Additional information

Funding

This work was supported by the CNRS (Centre National de la Recherche Scientifique) and Aix-Marseille University.