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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 12
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Original Articles

Synthesis of 5,6-dehydrokawain and some fluorinated analogues

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Pages 1482-1486 | Received 18 Jan 2018, Published online: 23 May 2018
 

ABSTRACT

An efficient methodology for the synthesis of 6-styrenylpyrone in a four-step sequence is reported. The reactions were performed under catalyst-free conditions with mild and affordable reagents to produce 5,6-dehydrokawain and fluorinated derivatives in good to excellent overall yields (72–86%) on a multigram scale. Two novel difluorinated derivatives are reported here for the first time.

GRAPHICAL ABSTRACT

Additional information

Funding

This work was supported by the University of KwaZulu-Natal and the National Research Foundation of South Africa (NRF) (Grant No: 98345, 2017).

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