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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 12
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Synthetic Communications Reviews

Pd-catalyzed regioselective C-H chlorination of disubstituted 1,2,3-triazoles

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Pages 1403-1412 | Received 21 Jan 2018, Published online: 23 May 2018
 

ABSTRACT

This paper mainly studied Pd-catalyzed regioselective chlorination of disubstituted 1,2,3-triazoles directed by the 1,2,3-triazole ring. A series of regioselective chlorinated products were synthesized in 47–86% yields using Pd(OAc)2 as a catalyst and CuCl2 as a chlorinated reagent. This method provides a new mean for the synthesis of 1,2,3-triazole halides which combines the formation of C-X bond with C-H activation.

GRAPHICAL ABSTRACT

Additional information

Funding

This work is supported by grants from the personnel training program of Kunming University of Science and Technology (KKSY201307094).

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