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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 13
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Original Articles

Wang resin-supported sulfonic acid-catalyzed multicomponent reaction in water leading to 4-oxo-4,5,6,7-tetrahydroindole derivatives

, , , &
Pages 1649-1656 | Received 16 Dec 2017, Published online: 08 Jun 2018
 

ABSTRACT

A greener approach for the synthesis of 4-oxo-4,5,6,7-tetrahydro indole derivatives has been achieved through Wang-OSO3H-mediated three-component reaction involving dimedone, phenacyl bromide, and primary amine in water. A variety of indole derivatives were prepared using this operationally simple and straight forward methodology in acceptable yields.

GRAPHICAL ABSTRACT

Additional information

Funding

The authors would like to thank Dr. H. Rama Mohan and the management of Dr. Reddy’s Laboratories Limited for giving support to perform this work. We also thank the analytical department of Dr. Reddy’s Laboratories for providing a timely support.

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