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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 13
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Original Articles

TEMPO/CuI synergetic catalyzed oxidative cross-coupling of indoles with benzylamines: Synthesis of bis(indolyl)phenylmethanes

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Pages 1694-1700 | Received 12 Feb 2018, Published online: 08 Jun 2018
 

ABSTRACT

TEMPO/CuI was found to be an effective catalyst for the cross-coupling of indoles with benzylic amines affording the corresponding bis(indolyl)phenylmethanes under air atmosphere at room temperature in good to excellent yields. The efficiency, easy workup, simplicity, and chemoselectivity of this protocol provide a green and low-cost procedure for the synthesis of these compounds.

GRAPHICAL ABSTRACT

Additional information

Funding

The authors are grateful to the Natural Science Foundation of Jiangxi Province (No: 20161BAB203096) for financial support.

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