Rh^III-catalyzed annulation of N-methoxyindozamides with heterobicyclic alkenes towards indolo[3,2-c]heteroarenes

Abstract

A rhodium-catalyzed annulation protocol towards indolo[3,2-c]-1-azaanthraenes and successive treatment with different acids, which offered diverse indolo[3,2-c]-heteroarenes, were herein demonstrated. The transition metal-mediated system offered a direct and facile approach towards the heterocyclic compounds of great significance, enjoying high efficiency and good functional groups compatibility.

Graphical Abstract

An annulation reaction between N-methoxyindozamides and heterobicyclic alkenes was herein disclosed. The Rh-Ag-cocatalyzed system offered a direct approach towards various indolo[3,2-c]-1-azaanthraenes in high efficiency and good functional group tolerance. Successive treatment of acids gave different products of great importance.

Keywords:

• Annulation
• heterobicyclic alkenes
• N-methoxyindo-zamides
• rhodium catalysis
• silver acetate

Additional information

Funding

The authors are grateful for the financial support from the Natural Science Foundation of Hunan Province (grant No. 2017JJ3027), the Fundamental Research Funds for Hunan University (grant No. 531107040840).