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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 14
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Synthetic Communications Review

Montmorillonite K-10 catalyzed Mannich reaction: Synthesis of aminonaphthoquinone derivatives from Lawsone

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Pages 1805-1815 | Received 21 Feb 2018, Published online: 18 Jun 2018
 

Abstract

An efficient one-pot protocol for the synthesis of 2-((substituted amino)(4-phenyl)methyl)-3-hydroxy-naphthalene-1,4-dione derivatives has been developed by the three-component reaction of 2-hydroxy-naphthalene-1,4-dione, aromatic aldehydes and anilines/heterocyclic amines using montmorillonite K-10 as a catalyst. The advantages of this method include short reaction time, excellent yield and easy work-up.

Graphical Abstract

Acknowledgments

S.J. is thankful to CSIR for providing Senior Research Fellowship (SRF).

Supporting information

This material can be found via "Supplementary Content" section of this article's webpage.

Additional information

Funding

This study was supported by Council of Scientific and Industrial Research (CSIR), New Delhi, India [Grants Reference no. 02(0172)/13/EMR-II, Dated: 21.10.2013].

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