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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 15
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Original Articles

Efficient synthesis of novel 6-substituted 2-(4-aryl-1,2,3-triazol-1-yl)pyrimidines and 7-deazapurinesFootnote*

, , , & ORCID Icon
Pages 1974-1985 | Received 03 Mar 2018, Published online: 28 Jun 2018
 

Abstract

A simple and efficient synthesis of 6-substituted 2-(4-aryl-1,2,3-triazol-1-yl)pyrimidines and 7-deazapurines from readily available 6-chloro-2-methylthiopyrimidine and 6-chloro-2-methylthio-7-deazapurine derivatives is described. The synthetic strategy is based on sequential reactions: substitution of 6-chlorine group with amines or (2-pyridyl)tributylstannane, oxidation of the obtained 6-substituted 2-methylthiopyrimidines, and 7-deazapurines to the corresponding 2-methylsulfonyl derivatives, their conversion to 2-azido derivatives and Cu(I)-catalyzed azide − alkyne cycloaddition reaction with arylethynes.

Graphical Abstract

Acknowledgment

The research was funded by Lithuanian–Latvian–Chinese (Taiwanese) Tripartite Cooperation Programme No. [TAP-LLT-01/2015].

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