Toward the synthesis of 1′E-isomer of ent-hyptenolide

Abstract

A short total synthesis of a diacetoxylated E,E-diene lactone ent-hyptenolide, was achieved involving from Phosphonate and cis-butene 1,4-diol. Brown Asymmetric allylation, Acrylation, Acetylation, Ring-closing metathesis as the key steps has been described. Moreover, the biological activity of ent-hyptenolide was evaluated on HeLa, A549, IMR32, and MDA-MB231 cancer cell lines. The ent-hyptenolide selectively and potently inhibited the growth of IMR32 cell line.

Graphical Abstract

Keywords:

• Anti reduction
• Brown's allylation
• cytotoxicity activity
• natural product
• ring-closing metathesis
• sposmolytic activity

Acknowledgments

We would like to thank Director, CSIR-IICT and the author KP thank CSIR, New Delhi, INDIA, for the financial support.