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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 16
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Original Articles

A convenient synthesis of the enantiomerically pure (S)-2,4-dihydroxybutyl-4-hydroxybenzoate using hydrolytic kinetic resolution

Namita A. MoreCSIR-National Chemical Laboratory, Division of Organic Chemistry, Pune, India; ;Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India; View further author information
,
Nitin L. JadhaoCSIR-National Chemical Laboratory, Division of Organic Chemistry, Pune, India; ;Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India; View further author information
,
Dinesh R. GarudDepartment of Chemistry, Sir Parashurambhau College, Pune, IndiaView further author information
&
Jayant M. GajbhiyeCSIR-National Chemical Laboratory, Division of Organic Chemistry, Pune, India; ;Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India; Correspondence[email protected]
View further author information
Pages 2093-2098 | Received 11 Apr 2018, Published online: 09 Jul 2018
 
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Abstract

(S)-2,4-Dihydroxybutyl-4-hydroxybenzoate was prepared in an extremely simple and practical way with high enantiomeric excess (99% ee) using Jacobsen’s Hydrolytic Kinetic Resolution technique as a key step and source of chirality.

Graphical Abstract

Additional information

Funding

This work was supported by DST-SERB (Ref. No. SERB/F/4617/2013-14; Dated: 17.10.2013).

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Related Research Data

A convenient synthesis of the enantiomerically pure (S)-2,4-dihydroxybutyl-4-hydroxybenzoate using hydrolytic kinetic resolution
Source: Figshare
A convenient synthesis of the enantiomerically pure (S)-2,4-dihydroxybutyl-4-hydroxybenzoate using hydrolytic kinetic resolution
Source: Figshare

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