Abstract
An efficient enantioselective approach to the syntheses of (−)-clavaminol A and deacetyl (+)-clavaminol H is presented, starting from n-decanol. The synthesis features Sharpless asymmetric dihydroxylation (AD), regioselective epoxide formation/opening and α-tosylation as key steps.
Graphical Abstract
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Acknowledgments
R. Pandey thanks Thapar Institute of Engineering and Technology for the research associateship and A.G. thanks UGC, New Delhi for research fellowship.