Focused microwave irradiation-assisted synthesis of N-cyclohexyl-1,2,4-oxadiazole derivatives with antitumor activity

Abstract

A facile synthesis of 3,5-disubstituted 1,2,4-oxadiazole derivatives under focused microwave irradiation (FMWI) is reported. Arylamidoximes 1a–i and dicyclohexylcarbodiimide (DCC) were carried out in DMF under FMWI to obtain 1,2,4-oxadiazoles 2a–i in 61–81% yields. All compounds exhibited antiproliferative activities in vitro against three human cancer cell lines HCT-116, PC-3, and SNB-19.

Graphical Abstract

Keywords:

• Antitumor activity
• arylamidoxime
• dicyclohexylcarbodiimide
• microwave
• 1,2,4-oxadiazole

Acknowledgment

Our tanks are extended to Analytical Centers CENAPESQ-UFRPE and DQF-UFPE.

Additional information

Funding

This work was supported by the National Council for Scientific and Technological Development – CNPq under Grant number 448082/2014-4; CAPES; and FACEPE-PRONEM under Grant number 0741.106/14.