Three-Component synthesis and characterization of nicotinamide derivatives containing a buta-1,3-diene-1,1,3-tricarbonitrile fragment

Abstract

The synthesis of nicotinamide derivatives containing a buta-1,3-diene-1,1,3-tricarbonitrile fragment through the base-promoted three-component reaction of an aromatic aldehyde, an acetoacetamide and malononitrile dimer in the presence of an oxidant is reported. The HOMO-LUMO energy levels were estimated by cyclic voltammetry and UV-Vis measurements. The influence of aryl and carbomoyl substituents on the optical and electrochemical properties was also investigated.

Graphical Abstract

Keywords:

• Cyclic voltammetry
• malononitrile dimer
• multicomponent reaction
• optical properties
• TCPy

Additional information

Funding

The research was performed under the financial support of the Russian Science Foundation (grant no. 17-13-01237.